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Author

Alexander E. Vinogradov

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Meta-analysis Open access Jul 2026

Inflamed Yet Immune-Evasive? A Transcriptomic Meta-Analysis Identifies Conserved Inflammatory, Developmental, and Neuronal Signatures Associated with Polyploid Giant Cancer Cells

This study proposes that PGCCs represent an immune-adaptive polyploid survival state in which inflammatory and ontogenetic pathways are repurposed to support immune evasion and tumor persistence and provides a framework for therapeutic strategies aimed at dismantling the PGCC reservoir and preventing tumor relapse.

O. Anatskaya, Alexander E. Vinogradov · 0 citations

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