Alexander D. MacKerell

Integrating Enhanced Molecular Sampling, RNA-Specific Scoring Functions, and SILCS Technology for Small-Molecule Targeting of RNA

Increasing knowledge of the wide range of biological functions of ribonucleic acids (RNAs) has made them a critical target in drug development. Accordingly, modifying their function by targeting them with small, drug-like molecules for the development of therapeutic agents is attractive. However, the rational design...