Open access
Aug 2026
J-domain proteins bridge the PKL and ATRX complex to transcription factors to fine-tune gene expression via H3.3 deposition
It is found that transcriptional outcome of PKL binding depends not only on the changes in H3.3 occupancy but also on the pre-existing chromatin context at PKL-targeted sites, which outlines a new mechanism for CHD3 chromatin remodeler recruitment and function.
Shu-Ya Wang, Colette L. Picard, Zhong-Shou Wu et al.
· bioRxiv · 0 citations