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Alexa Fernanda Uriostegui Navarro

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Review Open access Sep 2026

Pharmacogenomics in Emergency Care: Actionable Genetic Variability, Drug-Related Toxicity, and Precision Prescribing

Pharmacogenomic variability represents an increasingly relevant determinant of therapeutic response, drug toxicity, and treatment failure in emergency and internal medicine. This study analyzed the clinical applicability of actionable gene–drug interactions associated with acute pharmacological decision-making, severe...

Dayanna Estefania Fernández Astudillo, Cristian David Castro Hernandez, María Alejandra Galindo Van Strahlen et al. · 0 citations
Review Open access Aug 2026

Early Neuropsychiatric and Cutaneous Manifestations as Sentinel Signs of Systemic Disease

Systemic diseases may present with cutaneous, neurological, or psychiatric manifestations before the classical diagnostic phenotype becomes fully established, creating a clinically relevant prediagnostic window. This study analyzed the main neuropsychiatric and cutaneous manifestations associated with systemic lupus er...

Jocelyne Keren Hinojosa Villanueva, Luis Felipe Espinal Pérez, Juan José Parra Serpa et al. · 0 citations
Review Open access Aug 2026

Retinal Vascular Biomarkers for Neurovascular and Multiorgan Risk Assessment: From Fundus Imaging to Predictive Oculomics

Retinal microcirculation provides a unique opportunity to observe vascular alterations directly and noninvasively. This study analyzed its potential as a biomarker of cerebral and systemic vascular damage and examined emerging applications of fundus photography, optical coherence tomography, optical coherence tomograph...

Adrian Jhair Flores Equilea, Natalia Restrepo Hinestrosa, Juan José Parra Serpa et al. · 0 citations
Review Open access Jul 2026

CRISPR-Based Genome Editing in Contemporary Clinical Medicine: Therapeutic Translation, Global Challenges and the Future of Precision Medicine

CRISPR has progressed from an experimental genome-engineering technology to a clinically relevant therapeutic platform, although its future impact will depend on the ability to combine molecular precision and durable therapeutic benefit with rigorous safety assessment, responsible governance, and equitable access acros...

Gabriel Alejandro Ortega Moreno, Gerardo Amaya Villagran, A. González et al. · 0 citations

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