Abstract B005A: Tumor-enriched alternative splicing in pediatric central nervous system tumors reveals amyloid precursor protein exon 8 inclusion as a candidate therapeutic target
Abstract Alternative splicing (AS) is dysregulated in pediatric CNS tumors, including high-grade gliomas (HGGs) and atypical teratoid/rhabdoid tumors (ATRTs) which have poor survival outcomes and urgently need new therapeutic strategies. AS is increasingly being explored as a source of tumor-specific antigens for immun...