Apollo-IRE1: A Genetically Encoded Sensor for Live Cell and Multiplexed Imaging of Endoplasmic Reticulum Stress
Pancreatic beta cells face exceptional protein folding demands from high insulin production requirements, placing extraordinary stress on the endoplasmic reticulum (ER) and contributing to dysfunction in diabetes pathogenesis. Monitoring ER stress dynamics in living cells remains challenging due to the destructive natu...