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Author

Alex Inague

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Open access Sep 2026

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells.

Tumor reliance on antioxidant defenses creates a vulnerability to ferroptosis, yet strategies to therapeutically disable these systems remain limited. Here, we identify targeted degradation of the selenium uptake receptor lipoprotein receptor-related protein 8 (LRP8) as an effective approach to decrease the abundance o...

Fang-Zhu Zhao, Alex Inague, Trenton M. Peters-Clarke et al. · 0 citations

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