Alessandro Sette

Phase 2 Evaluation of two GEO-CM04S1 Dose Levels Shows Comparable Safety and Broad Immunogenicity.

BACKGROUND GEO-CM04S1 is a synthetic modified vaccinia Ankara (sMVA)-based SARS-CoV-2 vaccine expressing Spike (S) and Nucleocapsid (N) antigens derived from the ancestral Wuhan-Hu-1 reference strain. This phase 2 study evaluated the safety and immunogenicity of two GEO-CM04S1 dose levels administered as a single boost...

Durability and diversity of human upper airway T cell memory

Human lung organoid modelling of tissue-resident antiviral T cell responses.

Tissue-resident immunity constitutes a first line of defence against pathogens and enables rapid innate and adaptive memory responses1-3. However, experimental studies have been hindered by a lack of holistic human in vitro models that enable epithelial infection in the context of tissue-resident immune subsets. In lun...

CD4 Count and CD4/CD8 Ratio Impact Antibody Responses to COVID-19 mRNA Booster Vaccination in People with HIV on Suppressive ART.

CD4+ T cell count influences antibody persistence, while the CD4/CD8 ratio affects initial antibody magnitude and Tfh cell frequencies, highlighting complementary roles in shaping vaccine responses in PLWH.

Toward a Pan-Arenavirus T-cell Vaccine: Identification and Preclinical Evaluation of Conserved Epitope constructs 2260477

This work identified Conserved T cell Epitope Regions (CTERs) derived from conserved sequences within OWA and NWA, using LASV and JUNV as respective prototypes and represents an initial step toward the development of a pan-arenavirus T-cell vaccine.

Conserved CD4 T-cell responses correlate with antibody neutralization in solid organ transplant recipients after bivalent SARS-CoV-2 vaccination

The results emphasize the importance of conserved and cross-reactive responses in vaccine immunogenicity, providing a mechanism through which repeated boosting enhances vaccine immunogenicity in SOTRs and other immunocompromised populations.

Bivalent vaccination fails to enhance conserved spike T cell responses across BetaCoronaviruses 2260452

It is suggested that spike-based bivalent vaccination alone cannot direct a T-cell focused response to achieve broad immunity across the BetaCoronavirus family, and incorporation of additional protein sequences will likely be required to shift response toward the CTER approach.