Nutraceuticals and phytoceuticals are increasingly investigated for bipolar disorder (BD). We conducted a systematic review and network meta-analysis of randomized controlled trials (RCTs). PubMed/MEDLINE, EMBASE, Scopus, PsycINFO, and ClinicalTrials.gov were searched from inception to July 1, 2025. Co-primary outcomes...
M. Fornaro, Nicolas A. Nunez, C. Di Lorenzo et al.· European Neuropsychopharmaco...· 0 citations
BACKGROUND
Acute mixed bipolar/major depression is relatively frequent, yet quantitative information about its pharmacological management is relatively scant, warranting network meta-analysis (NMA) of comparative efficacy/response/acceptability of pharmacological interventions accounting for dose effects across differe...
M. Fornaro, C. Di Lorenzo, Nicolas A. Nunez et al.· Journal of Affective Disorde...· 0 citations
A meta-regression of efficacy effect sizes against adapted AMSTAR-Plus scores showed that larger SMDs were associated with lower AMSTAR scores, indicating lower study quality.
M. Fornaro, C. Di Lorenzo, Nicolas A. Nunez et al.· Molecular Psychiatry· 1 citation
Rigorous RCTs with standardized protocols, larger sample sizes, uniform dosing, and systematic biomarker investigations are needed to clarify ketamine’s neurochemical mechanism and optimize ketamine’s clinical application in treatment-resistant depression.
Balwinder Singh, Hossam M. Ali, Alessandro Miola et al.· Neuropsychopharmacology· 0 citations
Bipolar disorder (BD) is associated with facial emotion recognition (FER) deficits. Among these, impairments in recognizing moral emotions may be especially relevant to social dysfunction, but their relationship with brain structure remains poorly defined. In this cross-sectional case–control study, 48 euthymic adults...
Marialaura Lussignoli, G. Cattarinussi, Alessandro Miola et al.· European Archives of Psychia...· 0 citations
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