Silk fibroin nanoparticles coated with secretome-derived extracellular vesicles via GMP-ready microfluidics: a biomimetic carrier-in-carrier platform with preferential tumor cell internalization.
The integration of synthetic nanocarriers with biologically derived membranes represents a promising strategy to engineer biomimetic systems for precision medicine. Here, we report a hybrid nanoplatform in which silk fibroin nanoparticles (SFNs) are coated with the vesicular fraction of a GMP-compliant lyosecretome (he...