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Liver cancer incidences increase dramatically beyond 55 years of age, suggesting that age-associated changes contribute critically to tumor initiation. However, the mechanisms linking liver aging and cancer initiation remain incompletely defined. This study investigated the role of CD44, a marker of liver tumor-ini...
Conservation of SAA1-TLR4 signaling in human skeletal muscle identifies a therapeutically actionable tumor–host pathway and demonstrates that host deterioration can be targeted independently of tumor progression.
It is shown that the sulfotransferase CHST7 stabilizes fibroblast fate via CD44/JUNB signalling, and that its inhibition enhances cardiac reprogramming and improves heart repair, and defines a sulfotransferase-dependent barrier to cell fate conversion with therapeutic implications for heart regeneration.
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