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Author

Alejandro Sweet-Cordero

2 papers indexed here

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Open access Aug 2026

Surface and global proteomics identify ROR2 and other proteins as potentially actionable immunotherapeutic targets in osteosarcoma.

Osteosarcoma (OS) is the most common human primary bone cancer, primarily affecting children and young adults. While the survival rate of patients diagnosed with localized OS is ∼65%, this decreases to ∼20% for patients with metastatic disease, and recurrent disease remains largely incurable. Therefore, identifying new...

Brian Mooney, Xiaojie Chu, G. Negri et al. · 0 citations
Sep 2026

Abstract IA02: Single-cell regulatory network analysis of therapy-associated cell state remodeling to inform combination strategies in osteosarcoma

Intratumor heterogeneity and plasticity contribute to resistance, as coexisting tumor cell states exhibit non-overlapping drug sensitivities and divergent responses to therapy. Combination therapy design thus requires identifying vulnerabilities of treatment-persistent populations and measuring state-specific drug ef...

Jovana Pavisic, Chelsey M. Burke, Dao-Qi You et al. · 0 citations

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