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Author

Alberto Stolfi

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Open access Sep 2026

Fine-tuning neuron number: Lzts as a key regulator of neurogenesis and cell proliferation in Ciona

How progenitor mitotic timing is coupled to the number of neurons in a nervous system remains poorly understood, in part because most model systems have large, variable progenitor pools that obscure this relationship. The non-vertebrate chordate Ciona robusta offers a tractable alternative: its larval nervous system ar...

Paola Olivo, U. Coppola, M. Passero et al. · 0 citations
Open access Aug 2026

Using CRISPR/Cas9 to investigate the role of candidate human disease gene orthologs in Ciona

The results identify Pgm3 as the most promising candidate for further development as a Ciona-based model of human disease and demonstrate the utility of tissue-specific CRISPR screening for prioritizing candidate disease gene orthologs identified through comparative genomics platforms like Zoogle.

Sabrina A. Hernandez, Christopher J. Johnson, Alberto Stolfi · 0 citations

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