Leveraging high-throughput proteomics and AI-based protein folding to accelerate VAV1 molecular glue discovery
This study reports a series of CRBN molecular glues that selectively induce proteasomal degradation of VAV1, a hematopoietic-specific signaling protein and key target in hematological malignancies and autoimmune diseases. Using unbiased global proteomics, we identify phenyl-glutarimide derivatives (e.g., NGT-201-12) as...
Hanfeng Lin, Xin Yu, Haiyang et al.
· Nature Communications · 0 citations