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Author

Akshita Sinha

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Sep 2026

Decoding the off-target potency of DB18: A comparative structural study of CLK1 and TRK kinases.

This study identified a template compound that can be used to design homolog-specific inhibitors to resolve pan-TRK toxicity issues and elucidates functional aspects of DB18 responsible for its off-target specificity towards TRKA through rigorous structure-based investigations.

Sai Satya Sri Pulla, Vidya Jyothi Alli, Akshita Sinha et al. · 0 citations

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