Harnessing Artificial Intelligence for Microneedle-Mediated Transdermal Delivery of Stimulus-Responsive Nanocarriers: A New Frontier in Personalized Cancer Immunotherapy
Immunotherapy has transformed oncology, but immune-related adverse effects and suboptimal tumor accumulation often hamper conventional systemic delivery. Local delivery systems that integrate microneedles (MNs) with nanocarriers responsive to tumor microenvironments (TMEs) triggered by acidic, hypoxic, or enzyme-specif...