Rupioid Syphilis Beyond Immunosuppression: A Systematic Review of Cases in HIV-Negative Patients
Rupioid syphilis (malignant syphilis or lues maligna) is a severe ulcero-nodular manifestation of infection originating from Treponema pallidum. It is typically associated with immunosuppressed states, notably those derived from HIV co-infection. This systematic review aims to highlight the rare instances in which this...