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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Aikseng Ooi

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Sep 2026

Development of Isoform-Selective GRP78 Inhibitors from a Direct-to-Biology Strategy

The development of isoform-selective HSP70 inhibitors remains challenging due to the high conservation of this chaperone family. Continuing our efforts to target the peptide-binding pocket within the substrate-binding domain (SBD) of GRP78 (BiP/HSPA5), we identified compound 12 using a Direct-to-Biology (D2B) strateg...

Xiao-Yi Zhu, Qiu Li, Ke Wang et al. · 0 citations
Open access Aug 2026

NRF2-mediated ferroptosis suppression defines a cancer-specific vulnerability in tumors

This discovery fundamentally redefines the pathological role of NRF2 and positions NRF2 inhibition as a standalone, tumor-selective therapeutic strategy to eliminate Kras-driven malignancies by unleashing ferroptosis.

Dichun Huang, Mae Zhang, Ben N Stansfield et al. · 0 citations

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