Author

Aidan M. Cook

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Open access Jul 2026

BASELINE: a CRISPR base editing platform for mammalian-scale single-cell lineage tracing

BASELINE, which uses base editing to generate high-resolution lineage trees in conjunction with single-cell profiling, is introduced, which uses the Cas12a adenine base editor to irreversibly edit nucleotides across target arrays built from 50 synthetic target sites.

Evan Winter, F. Emiliani, Aidan M. Cook et al. · Nucleic Acids Research · 1 citation