Aida Contreras-Pérez

Cohesin preservation across mitosis contributes to restart transcription via Cdk9-mediated activation of RNAPol2.

Cohesin organizes 3D genome architecture yet its acute depletion in vitro minimally affects transcription, leaving its regulatory role puzzling. We hypothesized that cohesin function is relevant when first encounters chromatin after mitosis. Using in vivo labeling and cell-cycle synchronization in human cells, we demon...