Pharmacological manipulation of Sema4D by salvianolic acid A mitigates diabetic retinopathy via inhibiting PlexinB1/RhoA/ROCK/pMLC2 signaling cascade involved in endothelial dysfunction
Sal A treatment ameliorated retinal vascular abnormalities in diabetic mice, evidenced by increased VE-cadherin and NG2 expression, decreased α-smooth muscle actin (α-SMA) expression, and reduced acellular capillary formation, collectively restoring vascular integrity.