Engineering an F-Amine Dehydrogenase for Efficient and Sustainable Biocatalytic Synthesis of a Chiral PDE10 Inhibitor Precursor
(R)–4-(1H-indol-3-yl)butan-2-amine ((R)-4IBA), encompassing a nitrogen heterocycle and a chiral primary amino group, is a highly appealing precursor in the pharmaceutical domain. The direct amination of the readily available prochiral ketone 4-(1H-indol-3-yl)butan-2-one (4IBO) catalyzed by amine dehydrogenases (AmDHs...