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Aidong Zhang

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Open access Sep 2026

Assessing safety and trustworthiness of large language models in medicine

The remarkable capabilities of large language models make them increasingly compelling for use in real-world healthcare applications. However, the risks associated with using these artificial intelligence systems in medicine are not systematically understood. The aim of this study is to characterize these risks b...

Yi-Fan Yang, Qiao Jin, Robert Leaman et al. · 0 citations
Book Open access Aug 2026

Concept-Residual Representation Expansion for Robustness to Spurious Correlations

Concept-Residual eXpansion (CRX), a concept-augmented framework that improves robustness by expanding the set of candidate predictive features by improving robustness to spurious correlations, is proposed.

Eric Xie, Guang-Zhi Xiong, Wenqian Ye et al. · 0 citations
Book Open access Aug 2026

InfRL: Inference-time Reinforcement Learning for Research Idea Optimization

InfRL (Inference-time Reinforcement Learning) offers a practical and domain-agnostic approach to harness reinforcement learning during inference, bridging the gap between static prompting and computationally intensive parameter-level fine-tuning.

Sikun Guo, Amir Hassan Shariatmadari, Jiuqi Wang et al. · 0 citations
Book Open access Aug 2026

Curiosity-Driven Questioning for Engine-Agnostic LLM Research Ideation

Scientific ideation is driven by curiosity: researchers ask questions that expose knowledge gaps, reveal competing hypotheses, and clarify missing evidence relevant to decision making. Yet, most LLM-based ideation systems optimize the idea text while leaving curiosity under-modeled, resulting in brittle, engine-specifi...

Sikun Guo, Di Wang, Xiaohan Fan et al. · 0 citations
Book Open access Aug 2026

InfRL: Inference-time Reinforcement Learning for Research Idea Optimization

Large language models (LLMs) possess extensive latent knowledge yet remain largely static at inference. Once prompted, their generation policy typically cannot evolve, and post-hoc ''self-reflection'' methods provide no explicit principled learning signals. To address this limitation, we formally model iterative resear...

Sikun Guo, Amir Hassan Shariatmadari, Jiuqi Wang et al. · 0 citations
Book Open access Aug 2026

Concept-Residual Representation Expansion for Robustness to Spurious Correlations

Concept-Residual eXpansion (CRX), a concept-augmented framework that improves robustness by expanding the set of candidate predictive features by improving robustness to spurious correlations, is proposed.

Eric Xie, Guangzhi Xiong, Wenqian Ye et al. · 0 citations

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