Ahmed M. S. Hegazy

Chrysin-loaded casein nanoparticles protect against chlorfenapyr-induced renal injury through modulation of Nrf2/HO-1, NF-κB, and mitochondrial bioenergetics.

BACKGROUND Chlorfenapyr (CFP) is a pesticide that induces nephrotoxicity through oxidative stress, mitochondrial dysfunction, inflammation, and apoptosis. Casein nanoparticles may enhance the therapeutic efficacy of chrysin (CY). OBJECTIVE This study evaluated the protective effects of free CY and chrysin-loaded case...

Gallic Acid-Loaded Chitosan Nanoparticles Mitigate Methomyl-Induced Nephrotoxicity in Rats: Associations with Oxidative Stress, Inflammation, and Apoptotic Signaling

Enhanced hepatoprotective effects of fisetin-loaded liposomal nanoparticles against DEHP-induced liver injury in rats: modulation of oxidative stress, inflammation, apoptosis, and ferroptosis pathways.

FSN-LNPs provided enhanced hepatoprotection against DEHP-induced toxicity compared with free FSN, which was associated with attenuation of oxidative stress and inflammation and modulation of apoptosis- and ferroptosis-related pathways, likely due to improved bioavailability and cellular delivery.

Nano‐Rosmarinic Acid Protects Against Chlorfenapyr‐Induced Testicular Toxicity Through Modulation of NRF2/HO‐1 and NF‐κB/NLRP3 Signaling Pathways

Overall, RA‐loaded Chitosan nanoparticles provided superior protection against CFP‐induced testicular toxicity compared with crude RA, highlighting the potential of nanoformulation strategies to enhance RA's biological efficacy.