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Ahmed M. Reda

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Open access Nov 2026

Design, Synthesis, and Pharmacological Characterization of Novel Kappa Opioid Receptor Agonists via Isosteric Replacement Strategy for Inflammatory Pain

Pharmacokinetic studies identified compound 10 as a P-glycoprotein substrate with limited brain exposure, consistent with a CNS-sparing profile and preferentially peripheral activity, and was identified as a KOR-mediated antinociception candidate.

Ahmed M. Reda, Logan T. Neel, Celsey M. St. Onge et al. · 0 citations

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