Open access
Nov 2026
Design, Synthesis, and Pharmacological Characterization of Novel Kappa Opioid Receptor Agonists via Isosteric Replacement Strategy for Inflammatory Pain
Pharmacokinetic studies identified compound 10 as a P-glycoprotein substrate with limited brain exposure, consistent with a CNS-sparing profile and preferentially peripheral activity, and was identified as a KOR-mediated antinociception candidate.
Ahmed M. Reda, Logan T. Neel, Celsey M. St. Onge et al.
· Journal of Medicinal Chemist... · 0 citations