Exploiting sulfur transfer machinery in Mycobacterium tuberculosis: Discovery of novel CysA2-directed antitubercular leads.
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis strains highlights the requirement for new therapeutic targets and antitubercular chemotypes. CysA2, a sulfur transferase that participates in sulfur metabolism and redox homeostasis, is a relatively underexplored...