Effective tumor kinetics inferred from single routine H&E biopsies enable counterfactual virtual radiotherapy trials
Routine H&E-histopathology captures spatial snapshots of tumor ecosystems, yet computational pathology largely treats them as textures without explicit links to underlying kinetics. We show that patient-specific parameters of a mechanistic reaction-diffusion model can be inferred from a single biopsy. Cell-nucleus poin...
Pirmin Schlicke, Caner Ercan, Sara Ranjbar et al.
· medRxiv · 0 citations