Brain Region-Specific Peptide and Proteomic Signatures Inform Alzheimer’s Disease Biomarker Panels
Alzheimer’s disease (AD) is a heterogeneous neurodegenerative disorder with region- and severity-specific molecular signatures that complicate biomarker discovery. We combined peptide-centric quantitative proteomics data with machine learning, dimensionality reduction, nonlinear modeling, and network enrichment to id...