Author

Adriaan W. Bruijnzeel

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Open access Oct 2026

Chronic fentanyl induces sex-specific anxiolytic-like effects in opioid-dependent rats

Fentanyl is used as a treatment for severe pain, and it is a major contributor to opioid misuse and overdose fatalities. While it has been established that opioids are widely misused for their euphoric effects, little is known about the effects of chronic fentanyl exposure on anxiety-like behavior. We determined the ef...

Lara S. Caglayan, Fiona Zeyl, Enzo Gamba et al. · bioRxiv · 0 citations

Open access Sep 2026

Differential effects of nAChR modulators on impulsive action in a nicotine self-administration Go/No-Go task in rats

Introduction Tobacco use disorder is a chronic condition characterized by compulsive nicotine use, withdrawal, and relapse following abstinence. Impulsivity contributes to persistent nicotine use and poor cessation outcomes. This study examined whether nicotinic acetylcholine receptor (nAChR) modulators alter impulsive...

Ranjithkumar Chellian, G. Huisman, Lara S. Caglayan et al. · Frontiers in Pharmacology · 0 citations

Open access Jul 2026

Dissociable roles of dopamine D1 and nicotinic receptors in nicotine-motivated responding and impulsive action in a Go/No-Go self-administration task

Cigarette smoking remains one of the most important preventable causes of premature death worldwide. However, the mechanisms sustaining nicotine dependence and relapse are incompletely understood, particularly the role of impulsive action in persistent tobacco use. Dopamine D1 and nicotinic acetylcholine receptors both...

Ranjithkumar Chellian, G. Huisman, Lara S Caglayan et al. · bioRxiv · 0 citations