Author

Addison Pacheco

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Open access Aug 2026

Reduction of CXCR3+CCR6+ CD4+ T Cells and IL‐17+ RORγt+ CD4+ T Cells During Secukinumab Treatment Identifies Patients With Axial Spondyloarthritis Responsive to Subsequent Biologic Therapy

Objective We recently reported an immune profile that stratifies patients with axial spondyloarthritis based on clinical response to secukinumab. We now undertake an exploratory study on the secukinumab nonresponder patients to determine if immunologic changes occur during their initial secukinumab treatment that could...

Addison Pacheco, P. Remalante-Rayco, N. Haroon et al. · ACR Open Rheumatology · 0 citations

Aug 2026

T Cell Interferon and Cytotoxic Pathways in Axial Spondyloarthritis: Relationship to Secukinumab Response Profiles

Our study aims to define the difference in granzyme (GZMs) expression in axial spondyloarthritis (axSpA) patients that predisposes secukinumab treatment response. Secukinumab treatment response, as determined using BASDAI50 scoring at week 24, stratified patients into responders (SEC-R) and nonresponders (SE...

Addison Pacheco, Zoya Qaiyum, Melissa Lim et al. · Journal of Rheumatology · 0 citations

Aug 2026

STK17B/DRAK2 in Axial Spondyloarthritis: Expression Patterns in Blood and Tissue

Pre-biologic STK17B expression was higher among patients who were later identified as non-responders to IL-17i compared with responders, suggesting that DRAK2 upregulation contributes to axSpA-related inflammation and to treatment resistance, warranting further mechanistic investigation.

P. Remalante-Rayco, S. Jo, Addison Pacheco et al. · Journal of Rheumatology · 0 citations