Author

Adam C. Wilkinson

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Review Open access Sep 2026

Haematopoietic stem cell fitness mechanisms.

Haematopoietic stem cells (HSCs) are important for human health and clinical therapy. A heterogenous pool of HSCs sustain blood production through life by balancing self-renewal and multilineage differentiation. Aging is associated with a decline in the function of the HSC pool and haematopoietic perturbations. Additio...

Yavor K. Bozhilov, Hugo Vassort, Adam C. Wilkinson · Experimental Hematology · 0 citations

Nov 2026

Adult hematopoietic stem cells activate a normally fetal-restricted program to functionally expand ex vivo.

The ability to robustly expand transplantable hematopoietic stem cells (HSCs) ex vivo enables basic science and clinical therapies otherwise hindered by the scarcity of these self-renewing multipotent cells. Despite recent improvements in long-term ex vivo HSC expansion conditions, the molecular mechanisms required for...

Kyomi J. Igarashi, M. Nicholls, Leonid Olender et al. · Blood · 0 citations