Investigating the Influence of Dissolved Oxygen and pH Dynamics on Cell Growth, Metabolism and Recombinant Protein Production in High-Throughput Bioreactors
Dissolved oxygen (DO) concentration and culture pH are two of the most influential process parameters governing Chinese Hamster Ovary (CHO) cell physiology, metabolic activity, and recombinant protein production during upstream bioprocessing. Precise regulation of these parameters is essential for maximizing cell growt...