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Author

Abigail F. Quesnelle

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Open access Aug 2026

NU7441 reveals DNA-PK and BRD4 convergence as a therapeutic vulnerability in ovarian cancer

Evidence is provided that NU7441, traditionally classified as a selective DNA-PK inhibitor, also functions as a BRD4 inhibitor by directly displacing BRD4 from acetylated chromatin and it is suggested that multi-target inhibition of BRD4 and DNA-PK can be leveraged to support new therapeutic strategies.

Julie A. Disharoon, Brandon C. Johnson, Elizabeth A. Ampolini et al. · 0 citations

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