Open access
Aug 2026
The Ca2+ channel Orai3 drives gemcitabine resistance in pancreatic cancer through NFATc1-dependent SLIT3 expression.
Pancreatic Cancer (PC) is one of the most aggressive cancers and is associated with poor prognosis. One of the routinely used chemotherapeutic drugs for the treatment of advanced PC is gemcitabine, which offers survival benefits to patients. However, acquired gemcitabine-resistance leads to recurrence, metastasis, and...
Samriddhi Arora, Abhishek Tanwar, Gyan Ranjan et al.
· Journal of Biological Chemis... · 0 citations