Author

Abhishek Chatterjee

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Review Open access Sep 2026

Site-Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Traditional methods for protein bioconjugation, such as those targeting canonical amino acid residues, often suffer from a lack of site-specificity, yielding heterogeneous conjugates. Genetic code expansion (GCE) technology offers an exciting alternative, enabling site-specific incorporation of noncanonical amino acids...

R. Sarkar, Manas Joshi, Abhishek Chatterjee · Angewandte Chemie · 0 citations

Open access Sep 2026

Repurposing engineered aminoacyl-tRNA synthetases for proximity-dependent protein labeling through the release of aminoacyl-AMP intermediate

Over the past two decades, engineering efforts have yielded aminoacyl-tRNA synthetases (aaRSs) capable of charging diverse noncanonical amino acids (ncAAs). Here, we report an unexpected and exploitable activity of these engineered aaRSs: In the absence of their cognate tRNA, aaRSs can release the ncAA-AMP intermediate...

T. Yared, Elise D. Ficaretta, Lena A. Voss et al. · ACS Chemical Biology · 0 citations

2026

Site-Specific Chemical Conjugation of Recombinant Proteins onto the AAV Capsid.

This platform provides a powerful approach for engineering next-generation AAV vectors with customizable targeting profiles for diverse therapeutic applications and preserves AAV integrity and infectivity, and enables programmable retargeting of AAV tropism toward disease-relevant receptors.

Quan Pham, Jake Glicksman, Abhishek Chatterjee · Methods in molecular biology · 0 citations