Author

Abdulrahman M. Saleh

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Oct 2026

Design of 4-(piperazin-1-yl)thieno[2,3-d]pyrimidine derivatives targeting the DFG-out conformation of VEGFR-2: Synthesis, biological evaluations, and molecular modeling approaches.

Novel series of piperazinyl-thienopyrimidine acetamide derivatives (10a-l, 13a-b, and 16a) were rationally designed and synthesized as potential type II VEGFR-2 inhibitors based on the essential pharmacophoric features of sorafenib and the co-crystallized ligand in the VEGFR-2 crystal structure (PDB: 2OH4). The target...

Abdulrahman M. Saleh, Wagdy M. Eldehna, Mohamed R. Elnagar et al. · European journal of medicina... · 0 citations

Open access Aug 2026

Development of new imidazopyridine-based chalcones hybrids as potent antidiabetic and antioxidant agents: synthesis, in silico and in vitro evaluation

A novel series of six imidazopyridine-based chalcone hybrids is synthesized and evaluated their in vitro biological activities, including total antioxidant capacity, iron-reducing power, and radical scavenging (DPPH, ABTS, NO), as well as antidiabetic potential against α-amylase, α-glucosidase, and aldose reductase.

Hanan Abdelmawgoud Atia, Aladdin M. Srour, Hanaa Farag et al. · Scientific Reports · 0 citations

Open access Aug 2026

Targeting CDK‐2 With Novel Indole‐Pyrazole Hybrids: Discovery of Potent Anticancer Agents Supported by Mechanistic and In Silico Studies

The consistent binding of compound 5 d within the ATP‐binding pocket of CDK‐2 was confirmed by molecular docking and molecular dynamics simulations, and attractive drug‐like and pharmacokinetic features, similar to those of Roscovitine, were demonstrated by in silico ADMET predictions.

Wagdy M. Eldehna, Zainab M. Elsayed, Mohamed R. Elnagar et al. · Drug development research (P... · 0 citations