Author

Abdullah Alkhammash

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Open access Sep 2026

Quinazolinone–diarylpyrazole hybrids as dual EGFR/COX-2 inhibitors: antiproliferative, mechanistic, and in silico studies

Abnormal epidermal growth factor receptor (EGFR) signaling and cyclooxygenase-2 (COX-2) mediated inflammatory pathways contribute to tumor progression and survival, supporting their simultaneous pharmacological targeting. Herein, a series of quinazolinone–diarylpyrazole hybrids 7a–l was designed, synthesized, and evalu...

Abdullah Alkhammash, B. A. Saleem, Khulood H. Oudah et al. · RSC Advances · 0 citations

Sep 2026

Targeting TRAF6/MYD88/TLR4, Nrf2, and VEGF signaling pathways by Tranexamic acid as a Novel Therapeutic Approach Protects Against Isotretinoin-Induced Liver Toxicity in Rats.

BACKGROUND Isotretinoin is a widely prescribed retinoid for severe acne but is limited by dose-dependent hepatotoxicity. Tranexamic acid (TXA), an antifibrinolytic agent with emerging anti-inflammatory and antioxidant effects, may offer hepatoprotective potential. Aim: This study evaluated whether TXA mitigates isotret...

Abdullah Alkhammash, H. Hagar, Hatem Ali Ahmed Abdelmottaleb et al. · Immunopharmacology and immun... · 0 citations