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A. Zherdev

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Open access Sep 2026

Structure–Activity Relationship Analysis of Immunoassay Systems for (Fluoro)quinolones Detection

Detection systems for antibiotics of the (fluoro)quinolone (FQ) group are in high demand among food safety regulators and agricultural inspectors. At the same time, the application of developed test systems may be complicated by the significant structural diversity of related FQs (including enantiomeric forms), which n...

Platon P. Chebotaev, A. Buglak, N. A. Byzova et al. · 0 citations
Open access Jul 2026

G-quadruplex folding uncouples cis-activation from collateral trans-cleavage by Cas12a

The CRISPR/Cas12a system is widely used in nucleic-acid diagnostics because Cas12a couples guide-directed recognition of a cis-target with indiscriminate collateral trans-cleavage of ssDNA. Controlling these activities through DNA structure can tune diagnostic signals. G-quadruplexes (G4s) are strong structural regulat...

I. Safenkova, Maria V. Kamionskaya, A. V. Samokhvalov et al. · 0 citations

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