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Open access Oct 2026

Individualized Cardiac Index-Guided Hemodynamic Therapy in High-Risk Patients Undergoing Elective Major Abdominal Surgery: The PELICAN Randomized Clinical Trial.

Importance It remains unclear if intraoperative hemodynamic therapy should be guided by cardiac index. Objective To evaluate whether individualized cardiac index-guided hemodynamic therapy vs routine hemodynamic therapy improves outcomes in high-risk patients undergoing elective major abdominal surgery. Design, Set...

B. Saugel, Agnes S. Meidert, C. S. Meyhoff et al. · 0 citations
Open access Sep 2026

Belantamab mafodotin plus venetoclax in t(11;14)-positive relapsed or refractory multiple myeloma – the BELI(E)VE trial

The BELI(E)VE trial aims to establish a novel personalized therapeutic approach for a specific subset of MM patients by combining belantamab mafodotin and venetoclax, potentially inducing deep and durable remissions in t(11;14)-positive RRMM patients.

C. Schaefers, Cyrus Khandanpour, M. Hänel et al. · 0 citations
Open access Aug 2026

A longitudinal daily diary study of stress, self-esteem fluctuation, and mood variability in adolescents

Adolescence represents a developmental phase marked by profound and rapidly shifting emotional states. While some adolescents exhibit pronounced, day-to-day mood variability, others remain comparatively stable. Although emotional fluctuation has long been considered a core feature with implications for health and well-...

C. Borzikowsky, M. Prignitz, Stella Guldner et al. · 0 citations

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