Safety and Efficacy of Rational Polytherapy with Sodium Valproate and Lamotrigine for Pediatric Drug-Resistant Epilepsy: A Systematic Review and Meta-Analysis
Background: Drug-resistant epilepsy (DRE) affects approximately one-third of individuals with epilepsy, where seizures remain uncontrolled despite appropriate trials of at least two antiseizure medications (ASMs). Neuroinflammation, specifically chronic microglial activation, plays an important role in epileptogenesis,...