A. Yonehara

430. Investigating cellular phenotypes and genotypes of a preclinical model relevant to schizophrenia using single-cell RNA sequencing

These findings demonstrate that the ArxR264Q mutation induces early, cell-specific transcriptional dysregulation affecting pathways critical for cortical interneuron development, and provides mechanistic insight into how a schizophrenia-associated ARX variant may perturb early neurodevelopmental trajectories.