Aug 2026
Imbalanced p53-RB signaling triggers cGAS-STING-mediated immune activation in early oral cancer development.
Analysis of the TCGA-HNSC cohort showed that combined TP53/CDKN2A alterations significantly separated overall survival and were associated with distinct survival patterns, revealing a previously unrecognized mechanism by which imbalanced p53-RB signaling triggers tumor immunity during the early stages of oral carcinogenesis.
Zi-Chao Lu, Yasuhiro Mouri, Wenhua Shao et al.
· Oncogene · 0 citations