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Author

Astrid Weiss

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Open access Sep 2026

Vascular smooth muscle cell-derived osteoprotegerin drives pulmonary arterial hypertension via AKT activation and is attenuated by monoclonal antibody therapy.

AIM Pulmonary arterial hypertension (PAH) is driven by sustained vasoconstriction and structural remodelling of distal pulmonary arteries. We have previously demonstrated that osteoprotegerin (OPG, tnfrsf11b) is upregulated in PAH animal models and patient tissues, with circulating levels being prognostic. OPG knockout...

M. Keleş, Laura West, N. Arnold et al. · 0 citations
Open access Jul 2026

Differential multi-omics analysis of pulmonary arterial hypertension microvascular endothelial cells for differential drug response

Pulmonary arterial hypertension (PAH) represents a heterogeneous group of disorders that involves complex molecular dysregulations, which are not fully captured by single-omics analyses. We apply our network-based multi-omics analysis framework, DrDimont, to transcriptomic, proteomic, phosphoproteomic, and kinase scree...

P. Hiort, A. Weiss, Janina Krentz et al. · 0 citations

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