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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

A. Waters

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2 papers indexed here

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Open access Sep 2026

Myotonic Muscle Activity Drives a Persistent Pain State Responsive to NaV1.8-directed Analgesics.

Pain is a common and disabling feature of myotonic disorders, yet its biological basis remains poorly understood and no targeted analgesic therapies currently exist. Here, we demonstrate that skeletal muscle hyperexcitability is sufficient to initiate a persistent pain state independent of inflammation, nerve injury, o...

Tyler S. Nelson, Aida Calderon-Rivera, Heather N. Allen et al. · 1 citation · ⚡1
Open access Sep 2026

NaV1.7-dependent peripheral sensitization drives chronic pain in Parkinson’s disease

It is demonstrated that dopaminergic neurodegeneration initiated within the brain is sufficient to drive persistent peripheral sensory neuron dysfunction and identify CRMP2-dependent regulation of NaV1.7 as a therapeutic target for Parkinsonian pain.

Tyler S. Nelson, Naomi K. Grabus, Heather N. Allen et al. · 1 citation

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