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Author

A. W. Trafford

2 papers indexed here

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Open access Oct 2026

Non-invasive electrocardiographic imaging of torsades de pointes in an ovine model of drug-induced QT prolongation: recovery dispersion sets the stage, and abnormal impulse formation pulls the trigger

Torsades de pointes (TdP) arise from a dynamic spatiotemporal interplay between arrhythmogenic substrate and triggering events. Most existing in-vivo models investigating TdP rely on invasive surgical cardiac access, which alters electromechanical function of the heart and autonomic influences, thus limiting thei...

P. Deissler, M. Obeidat, J. Stoks et al. · 0 citations
Open access Aug 2026

Cardiac microtubules mediate transverse (t)-tubule growth and homeostasis

Transverse (t)-tubules enable rapid, synchronous Ca release required for efficient cardiac contraction by bringing L-type Ca channels into close apposition with ryanodine receptors. In heart failure with reduced ejection fraction (HFrEF), t-tubule disorganisation and loss occur alongside cardiac microtubule remodelling...

A. S. Whitley, G. W. P. Madders, A. Livesey et al. · 0 citations

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