Author

A. V. Zaykovskaya

3 papers indexed here

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2027

Synthesis, crystal structure, pharmacophore analysis and molecular docking of monoterpene-isatin conjugates as potential SARS-CoV-2 PLpro ligands with in vitro antiviral evaluation

A series of novel conjugates combining monoterpenoid fragments (camphor, fenchone) with an isatin scaffold was designed as potential SARS-CoV-2 PLpro inhibitors. Molecular docking and pharmacophore analysis confirmed their ability to bind to the active site of PLpro. Single crystal of target compound 12 was grown, the...

V. Oreshko, S. Borisevich, K. Kovaleva et al. · Журнал структурной химии · 0 citations

Review Open access 2026

Application Features of Boron-Containing Compounds and New Boron-Based Nanomaterials in Medicine and Oncology

This review examines modern methods for developing optimal nanocarriers for biomedical applications and new 2D boron-based nanomaterials (Xenes). The review highlights the key properties of borophene (conductivity, anisotropy, plasmonic and enzymatic properties), demonstrating the potential of borophene in diagnostics...

Yu. V. Tumanov, P. Gladyshev, E. D. Gribova et al. · Biomedical Chemistry Researc... · 0 citations

Open access Oct 2026

A two-component mRNA vaccine combining B-cell and T-cell immunogens of SARS-CoV-2 induces humoral and cellular immune responses in mice

INTRODUCTION. Despite the effectiveness of existing COVID-19 vaccines, the emergence of new SARS-CoV-2 variants necessitates the development of immunogens capable of eliciting a broad, cross-reactive immune response. A promising approach is the development of mRNA vaccines that induce both humoral and T-cell respons...

M. B. Borgoyakova, A. P. Rudometov, S. V. Sharabrin et al. · Biological Products. Prevent... · 0 citations