Alzheimer's disease (AD) is the most common cause of dementia, with global case numbers projected to reach 153 million in 20501. AD is highly heritable, with twin-based heritability estimates of 60-80%2. Although 1,200 causal loci are predicted to exist for AD3, approximately 80 loci have been associated with AD in two...
E. Uffelmann, D. Wightman, S. Bahrami et al.· Nature· 0 citations
Many AD pQTLs in CSF were enriched in neuroimmune activation, suggesting a genetic basis for neuroimmune dysregulation in AD, and how genetic variation shapes protein expression in the central nervous system is highlighted.
L. Reus, Chen-Yang Jiang, N. Vilor-Tejedor et al.· Molecular Neurodegeneration...· 0 citations
In a peripheral real-world memory clinic setting the BBMs demonstrated high concordance with clinically diagnosed dementia due to AD, suggesting utility of BBMs in peripheral memory clinic practice, in patients with suspected dementia.
Marleen Kloppenburg-Lagendijk, Claire Van Nyendaal, I. Verberk et al.· Journal of Alzheimer's Disea...· 0 citations
MRI-derived brain-PAD predicts progression to dementia in memory clinic patients with SCD or MCI and provided additional predictive value to visual rating scales in patients with SCD and mild cognitive impairment.
S. de Vries, K. Farkas, Hanneke F. M. Rhodius-Meester et al.· Neurology· 0 citations
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