Author

A. Turcan

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Open access Aug 2026

Conditional polygenic enrichment distinguishes causal from tagging disease-critical cell populations in single-cell RNA-seq

ScDRS-FM is introduced, a method that disentangles causal from tagging disease associations at single-cell resolution by jointly modeling correlated cell populations to assess conditional polygenic enrichment relative to other cell populations in the dataset; scDRS-FM further leverages single-cell denoising to improve...

A. Turcan, Kangcheng Hou, K. Z. Lin et al. · medRxiv · 0 citations

Open access Sep 2026

Genetic and cellular architecture of breast cancer risk across ancestries.

Results indicate substantial cross-ancestry sharing of breast cancer polygenic architecture, highlight a consistent contribution of regulatory variation, and identify convergent cellular contexts that motivate functional follow-up and inform expectations for the transferability and attainable performance of common-vari...

James L. Li, Maria Zanti, Jacob Williams et al. · JNCI Cancer Spectrum · 0 citations

Preprint Aug 2026

Population-Robust Feature Selection via Generalized Welfare Optimization

PopFS is introduced, a method for learning one shared, deployable feature set that is robust to population differences while letting each pop- ulation train its own model.

Ruiqi Lyu, A. Turcan, Bryan Wilder · 0 citations