Open access
Sep 2026
Regulation of Membrane Association and Downstream Effector Interaction of K-Ras by Its Hypervariable Region
The isoform-specific, farnesylated hypervariable region (HVR) of Ras plays an important role in the organization and oligomerization of its globular domain (G-domain) on the surface of the membrane and can control downstream effector binding by positioning the G-domain on the membrane in a specific orientation.
A. Trifan, Hossein Omidi Ardali, J. Vermaas et al.
· Membranes · 0 citations