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Author

A. Teunisse

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Open access Oct 2026

Chemogenetic ubiquitin E1 inhibitor TAK-243 CRISPR screen uncovers HAPSTR1/HUWE1 axis in chromatin proteostasis and cell cycle control

In this study, we sought to comprehensively map ubiquitin signaling networks at the crossroads of cellular proliferation and proteostasis, both crucial in cancer. Genome-wide CRISPR knockout screening in the presence of the ubiquitin E1 inhibitor TAK-243 identified 239 genes whose ablation sensitizes cells to ubiquitin...

N. V. van Overbeek, L. Clijsters, M. Wirth et al. · 0 citations
Open access Aug 2026

Genome-wide CRISPR-screening identifies p53 as regulator of cancer cell sensitivity to the histone evicting anthracycline aclarubicin

A genome-wide CRISPR screen to identify factors regulating sensitivity of cells to aclarubicin and identified p53 as a critical factor for cellular sensitivity suggests p53 could be an important factor to stratify patients for treatment with Aclarubicin.

Sabina Y. van der Zanden, Koen Schipper, Merle A. van Gelder et al. · 0 citations

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